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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can minimize panobinostat amounts by ~70% and lead to cure failure.Check Carefully (one)pentobarbital will lessen the level or impact of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.